Researchers at the Mount Sinai School of Medicine in New York have reversed depression-like behaviors in mice in an unexpected way. Rather than silencing the hyperactive neurons that triggered the rodents’ symptoms, the team boosted their activity even further. This triggered a compensatory, self-tuning response that brought the neurons’ firing—and the rodents’ behaviors—back to normal. “There’s a saying in Chinese: If you push something to an extreme, the only way it can go is in the opposite direction,” said Ming-Hu Han, who led the study, published today April 17 in Science. Although his team needs to confirm their results in humans, Han added, “it could give us new avenues for treating depression that are conceptually very different to the classical therapeutic strategy.” Rather than identifying the cause of an illness and reversing it, it may be possible to push those causes even harder and get the body to right itself.
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