The human brain has a prodigious demand for energy — 20 to 30% of the body’s energy budget. In the course of normal aging, in people with neurodegenerative diseases or mental disorders, or in periods of physiological stress, the supply of sugars to the brain may be reduced. This leads to a reduction in the brain’s energy reserves, which in turn can lead to cognitive decline and loss of memory.
But new research on mice shows that the brain’s energy reserves can be increased with a daily dose of pyruvate, a small energy-rich molecule that sits at the hub of most of the energy pathways inside the cell. These results need to be replicated in human subjects, but could ultimately lead to clinical applications.